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10.1007/s10741-018-9749-1 119 PatelP.KarchJ

Membrane melatonin G-protein coupled receptors are common on many, perhaps all, cells (155158) and when they bind melatonin, the activities of several antioxidative enzymes are stimulated, including SOD, GPx, glutathione reductase (GRd), CAT, and glutamate cysteine ligase (GCL), the rate limiting enzyme in glutathione production (21, 159, 160)

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This effect of maintaining the balance of Th1/Th2 and Th17/Treg cells may be related to the increase of L-arginine level to resist the uptake of M1 cells and produce NO

1 2 3 "IV Infusion: Explanatory Note"