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These findings indicate that a metabolic-based treatment that bypasses damaged glycolytic pathways and impaired mitochondrial activity may have beneficial therapeutic effects [35]
297 Mouse models of accelerated aging involve physically induced models (e.g., radiation and O3), chemically induced models (e.g., D-galactose and D-galactose-combined therapy), senescence-prone mice (e.g., SAMP), and premature aging models (e.g., HGPS) (Table 2)

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ABSTRACT Free radicals are common outcome o f no rmal aerob ic cellu la r metabolism
doi: 10.1016/j.bcp.2006.04.011 131 BogeskiIKapplRKummerowCGulaboskiRHothMNiemeyerBA
