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Metal-based antitumor compounds: beyond cisplatin

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PMID: 54 HuangJLiZHuYLiZXieYHuangHet al

ACA alone further enhances the survival of hippocampal cells by decreasing ROS generation [71, 72]

As an important regulator of iron uptake, TFR1 undergoes ubiquitination and degradation by -TRCP E3 ligase in a tribbles pseudokinase 2 (TRIB2)-dependent manner, consequently blocks ferroptosis in live cancer cells [64], but how does TRIB2 affect TRCP-mediated TFR1 degradation