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Another short feedback loop involves the participation of BMAL1/CLOCK to activate the expression of REV-ERB and ROR through binding to the nuclear orphan receptor ( ROR ) at the promoter site (62)

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The depressive status of the patients, as determined by the HRSD 17 scores, decreased over time with the drug treatment, from an average of 21.9 (4.9) at baseline to 11.6 (6.4) at week 4 and 8.6 (5.5) at week 8

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