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In Rheum palmatum , comparative transcriptomics and genome data have identified RpMYB factors that are significantly upregulated during methyl-jasmonate (MeJA)-induced AQ accumulation, and functional assays suggest that these MYBs directly activate key polyketide and tailoring genes (Zhao et al., 2024)
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Given the striking decrease of 55% of cells entering the S-phase of the cell cycle upon treatment with 2 ng/mL and 10 ng/mL of BPC 157 and decreased ERK phosphorylation, it was suggested that BPC 157 acts as an antimitogenic agent by preventing ERK phosphorylation and the propagation of the mitogenic signal via the MAPK signaling cascade, triggered by VEGF [95]
Aleffi S, Petrai I, Bertolani C, Parola M, Colombatto S, Novo E, et al
Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome
10.3390/healthcare12171721 282 LiuJ.WangF
