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doi: 10.3389/fnut.2022.718710 Received 01 June 2021 Accepted 22 February 2022 Published 25 April 2022 Volume 9 - 2022 Edited by Francisco Javier Santos Vicente, Vall dHebron University Hospital, Spain Reviewed by Markus Xie, Immunology Discovery, Genentech, United States

As with other incretin-based agents, these events were generally more common than with placebo and were often dose-related , particularly during the dose-escalation phase of treatment

The choice of supplementation method depends on the severity of the deficiency and the underlying cause

Vinarov et al., 2021)

Secondly, therapeutic heterogeneity: clinical trials exhibit marked heterogeneity, such as the efficacy of probiotics or prebiotics being influenced by the baseline microbiota of host, diabetic duration, and glycemic control, while the scarcity of large-scale, multicenter RCT data hinders the establishment of uniform treatment standards

What This Means Clinically For patients who have tried GLP-1 medications and experienced significant side effects, or who are not candidates for appetite-suppressing approaches, AOD 9604 represents a mechanistically different option