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These senescent T cells disrupt immune tolerance, promote autoreactivity against self-antigens, and exacerbate disease severity, particularly in RA patients with extra-articular manifestations (Fig
In another study, necrosis was observed in the liver and kidney of both pregnant rats and fetuses at doses approximately equal to the MHDD
Mashimo, T
[DOI] [PMC free article] [PubMed] [Google Scholar] [79].Suthanthiran M, Anderson ME, Sharma VK, Meister A
Diverse forms of programmed cell death encompass apoptosis, pyroptosis, necrosis, and autophagy [28, 29]
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