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Activation of the IL-6/Nox2 pathway in schizophrenia leads to the loss of the GABAergic phenotype of PV interneurons and decreased inhibitory activity in the prefrontal cortex [53] Inflammatory cytokines can affect the synthesis of monoamine neurotransmitters

These studies typically enroll a small cohort of 20 to 100 healthy volunteers, though patients with the target disease may be used for highly toxic medications like chemotherapeutics

PMID: 32127327 13

10.1007/s10637-015-0221-y 57

Ca Channel Figure 6

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