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Oxidative stress plays a significant role in PD pathogenesis, resulting from an imbalance between oxidants (ROS and RNS) and antioxidative mechanisms

NQO1 inhibition in combination therapy Coinhibition of GSTP1 and NQO1 shows antitumor potential in GBM, where EGFR mutations upregulate these enzymes to suppress ROS and drive tumor growth

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[DOI] [PMC free article] [PubMed] [Google Scholar] Teder T