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In Regard to Byun et al

Horvath, Marked elevation in plasma trimethylamine-N-oxide (TMAO) in patients with mitochondrial disorders treated with oral l-carnitine, Molecular genetics and metabolism reports 15 (2018) 130-133

In the current study, a marked elevation in MDA levels was recorded in the hippocampus and hypothalamus in PTZ-kindled animals

Trimethylamine-N-oxide (TMAO) response to animal source foods varies among healthy young men and is influenced by their gut microbiota composition: A randomized controlled trial
As reviewed elsewhere (Khanna et al., 2022), tear samples appear to be a reasonable reservoir of metabolites

Yes, antioxidants like Astaxanthin and Lycopene protect skin cells from oxidative damage, promoting healthier skin
