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Among these alkaloids, a subset has been pharmacologically characterized, revealing diverse and sometimes conflicting receptor interactions

[PubMed] [Google Scholar] 20.Pelicci G, Giordano S, Zhen Z, Salcini AE, Lanfrancone L, Bardelli A, Panayotou G, Waterfield MD, Ponzetto C, Pelicci PG

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Thus, FOXO4-DRI targets high SASP-expressing senescent cells that have naturally developed in the kidneys of fast aging Xpd TTD/TTD mice and in doing so restores kidney homeostasis