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It is a devastating disease with a lack of effective treatments and although the cause of the neuronal death in ALS is not known, it is suspected that oxidative damage plays a key role

(2005) Immunobiology: The immune system in health and disease, 6th edition

High glucose stimulates TNF and MCP-1 expression in rat microglia via ROS and NF-B pathways

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Consequently, combination strategies that concurrently target metabolic adaptation and bypass signaling are emerging as effective approaches to enhance efficacy and delay resistance

Zhang QY, Liu W, Li L, Du WH, Zuo CL, Ye XP, et al