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The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

While B12 can be obtained through diet, many people are deficient due to factors like poor diet, digestive issues, or lifestyle factors like age or vegetarian/vegan diets

It exists in a regulatory gray area as a research chemical

Glucagon rises beyond the bodys normal pulse range, adding liver- and visceral-fat effects along with much of the heart-rate increase

doi:10.1016/S0969-2126(98)00073-2

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