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47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy

This explains why topical applications achieve far lower tissue concentrations than injection

These compounds bind to receptors and trigger defined responses within the body

Mechanisms of drug resistance in cancer cells

Given the wide safety margin of B12 and the lower cost and greater patient comfort of oral regimens, future controlled studies should compare longterm neurological and hematological outcomes between routes