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Reduction in GSH is observed in the liver in streptozotocin (STZ)-induced rats and the oral supplementation of esculetin to diabetic rats for 45 days significantly brings it back near normalcy [93]

Chow OS, Patil S, Keskin M, Smith JJ , Widmar M, Smith DD, Avila K, Shia J, Chu P, Garcia-Aguilar J

This is particularly beneficial for adults over 65 and those with problems or previous surgery in the digestive tract

Experimental studies have demonstrated that GLP-1-positive cells and proglucagon mRNA, which play a role in mediating obesity and insulin resistance, were significantly reduced in the hippocampus and cortex of ob/ob mice compared to control mice (143)

ALI mouse model was established by injecting overdose (350 mg/kg) of APAP

113 Upon ligand engagement, the ER modulates the transcription of genes by binding to estrogen response elements in their promoter areas, thereby controlling gene expression