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Chang, Xiaoyuan Chen, Arta Monir Monjazeb and Jianping Xie for their contribution to the peer review of this work

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This reaction (Fenton reaction) forms free radical intermediates (alkoxy radicals and hydroxy radicals), which can induce secondary oxidation reactions which might lead to the dysfunction of biomolecules

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82,83 As a classical effector of RNAi, siRNA induces gene silencing by blocking mRNA translation

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