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Description
Such redox modifications have important metabolic consequences given the key roles these enzymes play in aerobic glucose metabolism
doi:10.1128/aac.00017-15 29
PON-1, paraoxonase-1
Single-cell transcriptomics and functional assays have illuminated that NRF2-active macrophages commonly reside in hemorrhagic regions of tumors and that the presence of RBC-heme drives the formation of tumor associated macrophages (TAMs) supportive of tumor growth and invasion which have characteristically high NRF2 and HO-1 and low MHC-II [19]
Very done
doi: 10.1074/jbc.M307146200
