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The emergence of new technologies like spatial transcriptomics and spatial metabolomics offers hope for identifying more potential metabolites in animal models, although effectively applying these methods to human samples remains a significant challenge

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This animal model also exhibit a dysregulation of Nrf2-dependent antioxidant responses in the vasculature, which promotes the development of marked endothelial dysfunction and endothelial apoptosis in the presence of increased oxidative stress[281], mimicking the aging phenotype

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