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Methods: An expert working group (EWG) comprising ten pulmonologists and a multidisciplinary drafting committee reviewed data from in vitro , mechanistic, animal and observational studies, randomized trials, reviews and meta-analyses for role of NAC in respiratory diseases

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Specific Adverse Effects Reported in Clinical Trials While the overall safety profile was excellent, clinical trials documented all adverse events regardless of severity or causality

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Los estudios clnicos publicados reportan una tolerancia cutnea excelente, sin irritacin significativa ni reaccin alrgica notable a las concentraciones utilizadas en las formulaciones tpicas (generalmente del 0,01 % al 1 %)

Pharmacometabolomics Pharmacometabolomics, also known as pharmacometabonomics, identifies nongenetic, environmental factors (e.g