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celastrol for 3 h and allowed to recover for 0, 3, 5, 8, or 11 h in culture medium

Approved pharmacological treatments, such as acetylcholinesterase inhibitors and the N -methyl-d-aspartate (NMDA) receptor antagonist memantine, provide only modest symptomatic relief and do not alter disease progression

2 Serum uric acid levels are typically considered elevated when they exceed ~7.0 mg/dL in men and 6.0 mg/dL in women

Bhatt DL, Steg PG, Brinton EA, Jacobson TA, Miller M, Tardif JC, Ketchum SB, Doyle RT Jr, Murphy SA, Soni PN, Braeckman RA, Juliano RA, Ballantyne CM