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This MTS consists of 36 amino acids located within the first NHR domain (Fig

To investigate whether CD37-deficiency affected lipid storage, WT and CD37KO lymphoma cells were analysed for the presence of lipid droplets

Some research suggests that TMAO could be beneficial for heart function

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However, TMAO inhibited the activity of pyruvate dehydrogenase (PDH) and weakened the oxidation of pyruvate in mitochondria, which impaired production of ATP (101)

As MASLD progresses from simple steatosis to Metabolic Dysfunction-Associated Steatohepatitis (MASH), it can lead to severe complications including fibrosis, cirrhosis, and hepatocellular carcinoma