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Acknowledgements We thank all the laboratory members for helping with reading and commenting on the manuscript

For example, MAPK activation is important for FSH-mediated StAR and progesterone synthesis, while blocking this cascade increases aromatase activity and E2 production (106, 126)

Then colonies were individually collected by trypsinization using 8 mm cloning cylinders (Pyrex, 09-552-21) and transferred to individual wells for expansion

GSSG was maximally produced under a physiological condition in the presence of 100 M cysteine with 1 mM GSH (Fig