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Pathogenic processes lead to ALS neurodegeneration, including mitochondrial dysfunction, apoptosis, chronic inflammatory reactions mediated by cytokine production, free radical generation, decreased neurogenesis, synaptic loss, synaptic death, excitotoxicity, axonal transport impairment, and neurotrophic factor dysregulation [137]

others prefer time-limited treatment followed by lifestyle maintenance

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Batch-specific documentation assists laboratories with product identification, traceability and research record keeping

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Semaglutide induced comparable reductions in body weight and food intake in both sexes but elicited distinct sex-specific changes in body composition