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doi: 10.1164/rccm.201510-1922OC 201 SouthernK

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It is a natural lipophilic AO and it is able to inhibit lipid oxidation and regenerate other oxidized AOs, such as vitamins C and E [18]

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When glutathione levels are depleted, detox pathways may become less efficient, allowing oxidative stress and inflammatory signaling to persist across multiple organ systems

Taken together, compound 1D228 may be a promising candidate for the next generation of c-Met and TRK inhibitors for cancer treatment, and offers a novel potential treatment strategy for cancer patients with abnormal expressions of c-Met or NTRK, or simultaneous of them