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Melanotan-2 remains a research compound with significant safety concerns and no approved indications Introduction# Melanotan-1 and Melanotan-2 are both synthetic analogs of alpha-melanocyte-stimulating hormone (alpha-MSH) developed at the University of Arizona, yet they differ substantially in structure, receptor selectivity, therapeutic applications, and safety profiles

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The term 'amelanotic' is often used to indicate lesions that are only partially devoid of pigment while truly amelanotic melanoma where lesions lack all pigment is rare

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We present a case of an aggressive sacral MMNST in a woman which demonstrated PRKAR1A, KMT2C, and GNAQ mutations, BRAF and MYC copy number gains, and PD-L1 overexpression