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The protein biomarkers include cytoplasmic aconitate hydratase (ACO1), argininosuccinate synthase (ASS1), fumarylacetoacetase (FAH), fructose-1,6-bisphosphatase 1 (FBP1) and carbamoylphosphate synthase (CPS1) ( In the past decade, using biomarkers to predict, monitor and diagnose drug-induced diseases during drug treatment or clinical trials has gradually gained wide attention among professionals ( 3.2 Predictive models for screening DILI 32% of post-approval withdrawals and 22% of clinical trial failures are caused by drug hepatotoxicity ( in vitro models for DILI risk prediction

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