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Reversal of inhibitors by immune tolerance induction (ITI), which involves repeated and prolonged administration of high FVIII doses, is currently the only approved strategy to eradicate inhibitors [141143]

GHK-Cu is one of the most studied peptides in skin biology

Additionally, it leverages the immunomodulatory effects of covalent inhibitors such as increased HLA expression and T cell infiltration to enhance therapeutic impact 24,25

Oral hygiene must be practiced to eliminate dry mouth conditions that lead to dental problems

Authors' Contributions Liu JR, Deng ZH, Zhu XJ, Zeng YR, Guan XX, and Li JH contributed to this paper

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