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There is also significant potential for the development mRNA particles against metastatic cancers, for immune modulation, protein replacement therapy and even genome editing with significant strides being made towards these applications in recent years 53 , and the successes of combination vaccines such as the mRNA -1083 and Pfizer/BioNTechs mRNA-1020/1030 could pave the way for the broadening of applications of these vaccines for health promotion

The results revealed that metformin treatment increased the percentage of follicular accumulation and luteinization, with a significant reduction in ovarian cysts in PCOS rats

ISS.):914

doi: 10.2337/db16-0020 90 LinWWuRTWuTKhorTOWangHKongAN

Ginkgolide B can protect dopaminergic cells by reducing intracellular calcium overload and caspase3 activity, and by restoring levels of calbindin (a calciumbinding protein), thereby aiding neuronal survival [49]