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Secondary outcomes Five included studies comprising 3605 patients reported change in MCV, four studies comprising 140 patients reported change in homocysteine levels, four studies comprising 3588 patients reported change in platelets count, and only three studies with 3430 patients reported change in WBC count

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Simultaneously, the preservation of SAM levels maintains cellular methylation capacity for essential epigenetic modifications and protein functions

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PMID 22972085

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