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Neuroinflammation in ME/CFS was initially suggested by studies showing elevated levels of pro-inflammatory cytokines, and decreased anti-inflammatory cytokines, in cerebrospinal fluid from lumbar punctures in ME/CFS patients [62, 63], and further supported by a positron emission tomography (PET) study [64], which showed increased binding of a radioligand to 18 kDa translocator protein (TSPO) receptor, the expression of which increases when microglia are activated

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When available, it can be helpful for carrier testing or prenatal diagnosis, discussed below

Mitochondrial dynamics and mitophagy in ASD Mitochondria are not static, they continuously change their morphology and distribution over the nervous system to match the current needs of the cells [309, 310]

doi: 10.1079/PNS2001110