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However, commonly used ferroptosis modulators are often associated with significant side effects, including pulmonary toxicity (Parry et al., 2002), liver damage, and neurotoxic effects (Zaafar et al., 2024)

Gene expression analysis of corpus callosum tissue shows upregulation of Tnf , Il-1b , Ccl2 , and Il-6 , cytokines and chemokines involved in BBB breakdown, as early as 57 days of cuprizone treatment

Both can affect appetite and weight, but they reach that endpoint through different receptor systems

Aug 2019;22(8):771-778

It interacts with SARS-CoV-2 as well as IAV and is reported in three CRISPR-Cas9 studies as a relevant host factor during SARS-CoV-2 infection 32,33,34