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One of these mechanisms is the reduction in the intracellular accumulation of cisplatin due to an increase in the thiol-containing protein-mediated inactivation, such as glutathione (GSH), a highly abundant and low-molecular-weight tripeptide (Glu-Cys-Gly), well known antioxidant in cells

The fatty acid synthase inhibitor cerulenin increases hepatic GSH content in some of the steatotic ob/ob mice administered cerulenin [23]

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Compared to other derivatives, artemisinin ether derivatives are more fat-soluble but less water-soluble, with low bioavailability ( Artemisinin and their derivatives have a wide range of pharmacologic effects, including anti-inflammatory, antioxidant, antifibrotic, and antitumor effects, in addition to their broad-spectrum antimalarial activity

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The underlying mechanisms enabling this reversible transition involve complex interplay between epigenetic modulation, transcriptional plasticity, metabolic rewiring, and microenvironmental interactions (illustrated in Figure 1)