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Importantly, tirzepatide may decrease the effectiveness of oral contraceptives, particularly during dose initiation and escalation

Because this element (henceforth referred to as the lid loop) is not highly conserved in sequence between LPLA2 and LCAT, it could play a role in determining their selectivity for N -acetylsphingosine (NAS) and cholesterol, respectively, as acyl acceptor substrates (see Discussion)

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TMAO can also up-regulate the number of scavenger receptors on the surface of macrophages (52)