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Retatrutide is a triple-receptor agonist peptide studied in metabolic research for its simultaneous activation of GLP-1, GIP, and glucagon receptors , making it the most advanced multi-pathway metabolic research compound currently available and representing the next generation beyond dual-receptor peptides like Tirzepatide and Semaglutide

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At 6 months, the rate of decline in ALSFRS-R was less than what had been measured in a 3-month lead in period, though this was not statistically significant [163]