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However, the NADPH-oxidase activity (which also uses NADPH as a cofactor) is increased (producing H 2 O 2 ) during active vitiligo, therefore increasing ROS and promoting an active competition with EAS enzymes for NADPH molecules, a molecule already reduced in active vitiligo patients (Shajil and Begum, 2006)

Bull Soc Fr Dermatol Syphiligr 48:518522 Touraine A (1941b) La mlanoblastose neurocutane

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