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1,6 Surgery is required when the symptoms of CD cannot be controlled using medication alone, and for complications such as bowel obstructions, abscess, fistulas, or perforated bowel

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These observations suggest CD8+ T cells are initially monospecific and reside in the pancreas as a default state, only becoming multi-specific and infiltrating the islet as pathogenesis advances

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Understanding health-related discussions on reddit: Development of a topic assignment method and exploratory analysis
