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A redox-inactive roGFP2 mutant was used as a control to distinguish genuine redox shifts from imaging artifacts

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This was evidenced by a significant inhibition of MPO and 5-LO activities and CRP levels by 55, 57, and 72%, respectively

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Our findings suggest that GSK-3 plays an important role in astrocytic differentiation of human glioblastoma cells and may be a novel therapeutic target in the malignant tumor.