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Recently, inflammasome activation of IL-1 and IL-18 has been implicated in atherogenesis (63,64)

Prolonged stimulation ultimately leads to VSMC apoptosis

Journal of Magnetism and Magnetic Materials

4.1.3 Long-term efficacy and safety The long-term safety profile and sustained therapeutic effects of stem cell transplantation remain incompletely characterized, necessitating rigorous longitudinal investigations to address critical knowledge gaps

This could in part be due to the lower levels of ApoE in the CNS of ApoE4 carriers (Flowers and Rebeck, 2020), thus offering less overall antimicrobial protection, but also mechanistically as ApoE4 prevents HSV-1 cellular attachment but crucially not viral entry or replication, and can also be incorporated into the HSV-1 virion that can enhance release from the cell (Feng et al., 2023), which would be an issue for viral AD

Furthermore, the model predicted patient-specific synergy and antagonism of efficacy and potency for combination of AXT050 with sorafenib, cabozantinib, and rilotumumab