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Headache and fatigue can occur, especially during dose increases

Jerlstrm-Hultqvist J, Einarsson E, Xu F et al (2013) Hydrogenosomes in the diplomonad Spironucleus salmonicida

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Enhanced mitochondrial function has also been observed, correlating with increased expression of genes involved in oxidative phosphorylation and thermogenesis

Heme is a chemoattractant, activates the complement system, modulates host defense mechanisms through the activation of innate immune receptors and the heme oxygenase-1/ferritin system, and induces innate immune memory

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