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BPC-157 and TB-500 operate through fundamentally different molecular mechanisms: BPC-157 modulates the nitric oxide system and upregulates growth factors including EGF, VEGF, and FGF-2 to promote cytoprotection and angiogenesis, while TB-500 sequesters G-actin monomers to regulate actin polymerization, cytoskeletal dynamics, and cell migration

LXR: liver X receptor

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Compared with those in normal skin fibroblast subpopulations, the expression levels of senescence- and inflammation-associated genes, including p16 (also known as CDKN2A ), SFRP4 18 , IGF1 19 , and IL1R1 were increased in keloid mesenchymal fibroblasts, whereas CCND2 , IL-6 , CXCL3 , and IL1R1 were increased in keloid pro-inflammatory fibroblasts (Fig

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This review systematically examines the multi-target mechanisms of SIRT1 in MASLD development and progression