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In intestinal Caco-2 cells, IL-1 decreases TER and increases inulin flux, which is in part mediated by the decreased expression and redistribution of occludin and increased expression of MLCK and MLC phosphorylation.46 It was also shown that the knockdown of nuclear factor-B p65 inhibits the decrease in occludin and increases in MLCK expression, indicating nuclear factor-B-dependent transcriptional regulation by IL-1.47 4

[PubMed] [Google Scholar] 105.PCO-02Safety and Pharmacokinetics Trial NCT02637284

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Injection Sites and Rotation Subcutaneous injection sites for CJC-1295: Abdomen: Most common