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Aldehydes are electrophiles (electron deficient species) that form covalent bonds with nucleophilic (electron rich) sites on biological targets

Strikingly, in a rat model of chronic unpredictable mild stress, rats that received ECT showed higher expression of ferroptosis negative regulators, including GPX4, NrF2, and ferritin heavy chain 1, in addition to lower expression of the ferroptosis-inducing ACSL4 [142]

MAbs 12 , 1703531

Global gene profiling reveals novel glucocorticoid induced changes in gene expression of human lens epithelial cells

Abstract Concepts regarding the operation of the ascorbateglutathione cycle and the associated water/water cycle in the processing of metabolically generated hydrogen peroxide and other forms of reactive oxygen species (ROS) are well established in the literature

This process is vital for safeguarding the cell membranes structure and function against oxidative stress and damage (32)