foxo4-dri senolytic mice baar 2017 Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging FOXO4-DRI

A recent study has implicated an effect of LA on MLC through inhibition of pMLC (47)

One trial evaluated TB4 for heart health, finding that the peptide could protect and repair the heart in patients with acute myocardial infarction, and a separate trial found that TB4 improved outcomes during congenital heart surgery.21 The review also mentions a few clinical trials related to eye health, with results showing that TB4 can reduce eye dryness, relieve ocular discomfort, lower inflammation in the conjunctiva, and more

In alignment with these substrate shifts, the peak lactate response to intensive exercise is significantly lower during the luteal phase, a phenomenon attributed to reduced lactate appearance rates and slower carbohydrate turnover compared to the follicular phase [103]

Endocrine Effects of Relative Energy Deficiency in Sport

GTEx Consortium

In addition, there was limited efficacy, and a lacking of curative effects in the original cytoprotection implementation by prostaglandins given (pleiotropic) beneficial effects occurring mostly with application before injury induction [42]