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116 Mitochondria and inflammation Inflammation is a defense response to the stimulation of inflammatory factors, which usually occurs with pathological changes such as cell necrosis and inflammatory cell infiltration

e-mail: [email protected] This article was submitted to Frontiers in Experimental Endocrinology, a specialty of Frontiers in Endocrinology

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This "energy sink" literally starves the brain, heart, and skeletal muscles of energy, directly causing the hallmark symptom of post-exertional malaise (PEM) and the severe exercise intolerance seen in these conditions

doi: 10.1002/hep.510230521

doi:10.1136/emj.20.4.366