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(2021) clearly indicated that hydrogen-saturated saline mediates neuroprotection through autophagy via the PI3K/AKT/mTOR pathway during the early and medium stages of rotenone-induced PD in rats

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In a murine model of malaria infection, andrographolide significantly decreased the levels of proinflammatory cytokine IFN- and improved the levels of anti-inflammatory cytokines IL-10 and IL-4, and the mechanism may have partly involved the regulation of serine/threonine kinase and GSK3 and inhibition of the NF-B pathway ( 11 Safety testing of andrographolide and its derivatives Although andrographolide and its derivatives have good anti-inflammatory effects, they also have certain biological toxicity and adverse reactions