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While NETs serve as a beneficial defense strategy against pathogens by trapping and combating bacteria, fungi and protozoa (92), in sterile inflammation such as HIRI, 'suicidal NETosis' (that is, neutrophil programmed death associated with NET release) predominantly occurs

Subjective changes: pain, range of motion, skin appearance, and any unusual symptoms

Lack of robust human clinical trials prevents confirmation of consistent outcomes, optimal dosing, or long-term safety

Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: evidence for a common genetic vulnerability

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BMC Cancer 25 (1), 644