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2 Molecular mechanisms of ferroptosis In 2003, the Stockwell Lab identified a non-apoptotic form of cell death when they used the small molecule erastin to stimulate the oncogenic RAS-mutant human cancer cell line while screening anticancer drug libraries (Yang and Stockwell, 2008)

In the non-canonical pathway, LOS on OMVs or intracellular bacteria is first recognized by guanylate-binding proteins (GBPs) that recruit caspase-4 (murine caspase-11) (Vanaja et al., 2016

Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia

Weight loss, diarrhea, stomach discomfort, and rectal bleeding are a few of the symptoms of them, but inflammation is the major characteristic shared by them [3]

Other ingredients: Excipients and Colours (Red Oxide of Iron and Caramel)

FIGURE 2 5.2 Clinical application of intranasally delivered drugs Although IN delivery of iron chelators remains in the early preclinical stages and has not yet entered clinical trials, the broader field of IN route has gained increasing attention over the past decade, as evidenced by a notable rise in related clinical studies