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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

In addition to 5-amino-1MQ, JBSNF-000088 is another NNMT inhibitor that is promising for treatment of obesity and associated T2D

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doi: 10.1038/s41573-020-0075-7

L., Burchard J., Schelter J., et al

[DOI] [PubMed] [Google Scholar] 17.Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ