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-Synuclein conformational strains as drivers of phenotypic heterogeneity in neurodegenerative diseases

Zinc supports this interplay by maintaining antioxidant enzymes, including peroxisomal Cu/Zn-SOD and mitochondrial SOD1, and by regulating redox signaling pathways 97

The glutathione disulfide (GSSG) formed can be recycled to GSH by glutathione reductase in the presence of NADPH

In the pathological progression of PD, the inflammatory response initiated by aberrant microglial activation plays a crucial role in the degeneration of dopaminergic neurons