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But while B vitamins have been studied for their potential positive effects on heart health, they are not currently recommended for treatment or prevention of hypertension

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Sampson CM, Dimet AL, Neelakantan H, Ogunseye KO, Stevenson HL, Hommel JD, Watowich SJ (2021) Combined nicotinamide N -methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice

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And the inconsistent bioavailability of oral formulations means some percentage of users are paying for convenience while getting subtherapeutic blood levels
